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J Biol … The use of PCR and microarray technology has revealed the EPO receptor (EPOR) to be consistently selectively expressed, ectopically, in ETV6-RUNX1 + ALL, although the presence of a functional receptor on the cell surface and its role, if any, in leukemogenesis driven by ETV6-RUNX1 remains uncertain. 27-29 Inthal et al have shown that EPO enhances proliferation of ETV6-RUNX1 + leukemia and attenuates the … The aryloxy-pyrimidinediamine, AF-219 (Ford et al., 2013; Smith et al., 2013) is an orally active small molecule (Mol Wt. ∼350 Daltons) antagonist at human P2X3-containing receptors. The inhibitory potency (IC 50) of AF-219 has been reported as ∼30 nM versus recombinant hP2X3 homotrimers and 100–250 nM at hP2X2/3 heterotrimeric receptors, potencies very similar to those Receptor ID Address Receptor ID Address Faskally, Killiecrankie, Perth And Kinross, PH16 5LG R5.031 Old Faskally, Lodge 4, A9T From The Overbridge At The B8079 To The Entrance To Kennels Faskally, Killiecrankie, Perth And Kinross, PH16 5LG R5.215 Railway Cottages, 11 Ford Road, Blair Atholl, Perth And Kinross, PH18 5SQ The recent discovery that the ROR2 receptor tyrosine kinase (RTK) is a novel Wnt receptor provides the potential to target the non-canonical Wnt pathway for cancer treatments. As a member of the RTK superfamily of surface receptors ROR2 appears to possess dual roles as a tumor suppressor or activator depending on tumor type.

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We previously showed that a fructose-enriched diet does not increase blood pressure in rats unless it is combined with high salt intake. This effect was accompanied by a large increase in phosphorylation of the renal Na/K/2Cl cotransporter NKCC2 at threonine 96/101.

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